When we eat, blood sugar stimulates the pancreas to secrete insulin and help glucose enter into the body cells. Insulin Resistance happens when the body cells ignore the message delivered by insulin and do not allow the glucose to enter into the cells. This leads to a high sugar level inside the blood. The pancreas senses the situation of hyperglycemia, and strains to release insulin. Therefore, people who have Insulin Resistance usually have high sugar levels in the blood and a higher concentration of insulin than is normal.